Institute for Mummy Studies - Projects - EvolTB

EvolTB

Illuminating the evolutionary history of the Mycobacterium tuberculosis complex (MTBC)

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Project duration: October 2018 - September 2022
Project status: finished
Funding:
Internal funding EURAC (Project)
Institute: Institute for Mummy Studies

To date, tuberculosis is one of top ten causes of death in the world. Recent approaches to stop the spread of this disease often fail because of the lack of knowledge about the evolutionary past of its causing agent Mycobacterium tuberculosis. Skeletal changes in ancient human remains prove that tuberculosis has been a scourge of mankind for several thousand years. Yet, investigations on a molecular level remain difficult due to poor conservation and high environmental contamination of samples.

In this project, we aim to reconstruct ancient Mycobacterium tuberculosis complex (MTBC) genomes by using an interdisciplinary approach. First, we aim to optimize an enrichment technique that targets MTBC specific DNA. Next, we will produce high resolution ancient genomic data by next-generation sequencing and apply computational biological tools to understand the onset and development of this pathogen.

Publications

Multidisciplinary study on the role of bone lesions in the paleopathological diagnosis of tuberculosis in ancient human remains
Zink A, Kanik J, Lerchl J, Mari B, Lee J, Harbeck M, Maixner F (2024)
Presentation/Speech

Conference: European Meeting of the Paleopathology Association PPA | Leiden | 21.8.2024 - 24.8.2024

Metagenomic analysis of Mycobacterium tuberculosis in ancient human remains
Jäger HY (2023)
PhD thesis

More information: https://edoc.ub.uni-muenchen.de/32996/6/Jaeger_Heidi_Yoko.pd ...

Paleopathology and evolution of tuberculosis editorial
Pálfi G, Dutour O, Hajdu T, Sola C, Zink A (2023)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2023.102428

Tuberculosis in mummies: New findings, perspectives and limitations
Zink A, Maixner F, Jäger HY, Szikossy I, Pálfi G, Pap I (2023)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2023.102371

Re-examination of the Subalyuk Neanderthal remains uncovers signs of probable TB infection (Subalyuk Cave, Hungary)
Pálfi G, Molnár E, Bereczki Z, Coqueugniot H, Dutour O, Tillier A, Rosendahl W, Sklánitz A, Mester Z, Gasparik M, Maixner F, Zink A, Minnikin DE, Pap I (2023)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2023.102419

Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary
Lee OY-C, Wu HHT, Besra GS, Minnikin DE, Jäger HY, Maixner F, Zink A, Gasparik M, Pap I, Bereczki Z, Pálfi (2023)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2023.102420

Hit or miss: A metagenomic evaluation of intra-bone variability of host pathogen load in tuberculosis-infected human remains
Jäger HY, Atz Zanotelli D, Maixner F, Nicklisch N, Alt KW, Meller H, Pap I, Szikossy I, Pàlfi G, Zink A (2023)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2023.102392

Metagenomic analysis reveals mixed Mycobacterium tuberculosis infection in a 18th century Hungarian midwife
Jäger HY, Maixner F, Pap I, Szikossy I, Pálfi G, Zink AR (2022)
Journal article
Tuberculosis

More information: https://doi.org/10.1016/j.tube.2022.102181

https://doi.org/10.1016/j.tube.2022.102181

A rare case of calvarial tuberculosis from the Avar Age (8th century CE) cemetery of Kaba–Bitózug (Hajdú-Bihar county, Hungary): Pathogenesis and differential diagnostic aspects
Spekker O, Varadi OA, Szekeres A, Jäger HY, Zink A, Berner M, Pany-Kucera D, Strondl L, Klostermann P, Samu L, Kiraly K, Bereczki Z, Molnar E, Palfi G, Tihanyi B (2022)
Journal article
Tuberculosis

https://doi.org/10.1016/j.tube.2022.102226

Verification of tuberculosis infection among Vác mummies (18th century CE, Hungary) based on lipid biomarker profiling with a new HPLC-HESI-MS approach
Váradi OA, Rakk D, Spekker O, Terhes G, Urbán E, Berthon W, Pap I, Szikossy I, Maixner F, Zink A, Vágvólgyi C, Donoghue H, Minnikin D, Szekeres A, Pálfi G (2021)
Journal article
Tuberculosis

More information: https://doi.org/10.1016/j.tube.2020.102037

https://doi.org/10.1016/j.tube.2020.102037

https://hdl.handle.net/10863/16368

Lipid biomarker based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary)
Váradia OA, Szikossy I, Spekkera O, Rakk D, Terhes G, Urbán E, Berthon W, Pap I, Maixner F, Zink A, Vágvölgyi C, Donoghue HD, Minnikin DE, Pálfi´G, Szekeres A (2020)
Journal article
Acta Biologica Szegediensis

More information: http://abs.bibl.u-szeged.hu/index.php/abs

https://doi.org/10.14232/abs.2020.2.99-109

https://hdl.handle.net/10863/16814

TB, or not TB, that is the question! Molecular evolutionary analysis of tuberculosis in ancient human remains
Maixner F, Jäger HY, Pap I, Szikossy I, Pálfi G, Zink A (2019)
Presentation/Speech

Conference: Health and Life in Ancient Egypt - Mummies in Focus Conference | Budapest | 27.8.2019 - 30.8.2019

https://hdl.handle.net/10863/13032

Approche d´enrichissement en solution ciblant l´ADN génomique du complexe Mycobacterium tuberculosis (CMTB) provenant de vestiges humains archéologiques TB-positifs
Jacqueroud C, Maixner F, Granehäll F, Molnár E, Pálfi G, Zink A, Dutour O (2018)
Presentation/Speech

Tuberculosis in early medieval Switzerland: osteological and molecular evidence from Courroux
Cooper C, Fellner R, Heubi O, Maixner F, Zink A, Lösch S (2016)
Journal article
Swiss Medical Weekly

https://doi.org/10.4414/smw.2016.14269

https://hdl.handle.net/10863/6670

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