To gain a better understanding of the development of atherosclerotic cardiovascular disease (ASCVD), a genetic tool was developed to investigate the prevalence of disease-associated mutations in ancient human populations. Therefore, the physical occurrence of calcified plaques in 22 mummified remains from four different continents (CT scans) was compared with their genetic predisposition based on a newly designed targeted enrichment capture and calculated polygenic risk scores (PRS).

Find the complete information here: https://doi.org/10.5334/aogh.4366