Istituto per lo studio delle mummie - Projects - MUMMY ATHEROSCLEROSIS

MUMMY ATHEROSCLEROSIS

Valutazione dei collegamenti mancanti nell'aterogenesi, attraverso la paleogenetica, la tomografia computerizzata e l’analisi degli isotopi stabili.

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Project duration: September 2014 - September 2024
Project status: finished
Funding:
Internal funding EURAC (Project)
Institute: Istituto per lo studio delle mummie

In questo progetto vogliamo indagare l'evoluzione delle cause genetiche ed ambientali, note e nuove, dell´ aterosclerosi. In particolare, la presenza e l'entità dell’aterosclerosi in relazione ai fattori genetici e ambientali saranno confrontati in differente popolazioni. Popolazioni composta da mummie, sia naturali che antropogeniche, provenienti da culture di tutto il mondo e risalenti a 6000 anni fa. Inoltre, il genoma di queste popolazioni sarà confrontato con quello riscontrato nelle prime popolazioni umane incluso Neanderthal e l'ominide Denisova. Le tecniche di indagine includono la tomografia computerizzata ai raggi X per confermare a livello fenotipico la presenza di aterosclerosi in mummie con tessuti molli ben conservati. Inoltre, i campioni verranno sottoposti all’analisi degli isotopi stabili e infine, alla caratterizzazione dell’intero genoma.

I risultati permetteranno di valutare l’entità dell’aterosclerosi nelle popolazioni, tramite la raccolta del materiale genomico, e di determinare la variabilità del genoma nelle popolazioni studiate, nonché la correlazione tra il genoma e il fenotipo.

Publications

Genetic Predisposition of Atherosclerotic Cardiovascular Disease in Ancient Human Remains
Wurst C, Maixner F, Paladin A, Mussauer A, Valverde G, Narula J, Thompson R, Zink A (2024)
Articolo su rivista
Annals of Global Health

https://doi.org/10.5334/aogh.4366

Atherosclerosis in ancient mummified humans: the global HORUS study
Thompson RC, Sutherland ML, Allam AH, Paladin A, Zink AR, Wann LS, Sutherland JD, Frohlich B, Hunt D, Miyamoto MI, Rowan CJ, Michalik DE, Finch CE, Lombardi GP, Soliman M, Monge JM, Vallodolid CM, Cox SL, Abdel-Maksoud G, Badr I, Nur el-Din A, King SI, Seyfried F, Panzer S, Zesch S, Wurst C, Samadelli M, Gregori G, Rossani M, Valverde G, Maixner F, Facchetti F, Warnasch S, Watson L, Narula J, Nelson AJ, Thomas GS (2024)
Articolo su rivista
European Heart Journal

https://doi.org/10.1093/eurheartj/ehae283

Genetic study of Predynastic to early Islamic ancient Egyptian human remains
Mussauer A, Wurst C, Paladin A, Coia V, Maixner F, Zink A (2024)
Presentazione

Conference: Mummies and the Ancient Egyptians | Budapest | 29.1.2024 - 2.2.2024

Genetic Predisposition of Atherosclerotic Cardiovascular Disease in Ancient Human Remains
Wurst C (2024)
Presentazione

Conference: Monthly meeting of the HORUS-Tsimane study group | online | 16.3.2024 - 16.3.2024

The Gebelein Mummies: a review of the human remains and archaeological objects of Dr C. Reinhardt in the Berlin collection
Kuhn R, Teßmann B, Paladin A, Salem N, Sutherland ML, Zink A, Wurst C, Rosendahl W, Zesch S (2024)
Presentazione

Conference: 8th International Conference “Egypt at its Origins” on Predynastic and Early Dynastic Egypt | Kraków | 16.9.2024 - 20.9.2024

Atherosclerotic cardiovascular disease in mummies: a polygenic risk score based on a genetic enrichment approach
Wurst C, Maixner F, Paladin A, Mussauer A, Valverde G, Thompson R, Zink A (2023)
Presentazione

Conference: New Horizons in Biomolecular Archaeology (ISBA10) | Tartu | 13.9.2023 - 16.9.2023

Genetic study of ancient Egyptian human remains dating from the Predynastic Period to the early Islamic Period (ca. 4000 cal. BCE - 800 cal. CE)
Mussauer A, Wurst C, Paladin A, Coia V, Maixner F, Zink A (2023)
Presentazione

Conference: New Horizons in Biomolecular Archaeology (ISBA10) | Tartu | 13.9.2023 - 16.9.2023

The Genetic Background of Atherosclerosis in Ancient Mummies
Zink A, Wurst C, Maixner F, Wann S, Thompson RC, Thomas GS
(2023)
Contributo in un libro
The Bioarchaeology of Cardiovascular Disease

https://doi.org/10.1017/9781108648561.007

Atherosclerosis among the Elites: A Bioarchaeological Investigation of Seventeenth- to Nineteenth-Century Mummified Human Remains from Palermo, Sicily (Italy) and Vilnius (Lithuania)
Piombino-Mascali D, Jankauskas R, Zink A, Panzer S (2023)
Contributo in un libro
The Bioarchaeology of Cardiovascular Disease

https://doi.org/10.1017/9781108648561.009

Molekulargenetische Untersuchung einer Mumie
Wurst C, Sarhan SM, Maixner F, Zink A (2023)
Articolo su rivista
BIOspektrum

Ulteriori informazioni: https://link.springer.com/article/10.1007/s12268-023-1982-z

https://doi.org/10.1007/s12268-023-1982-z

Atherosclerotic cardiovascular disease in mummies: A polygenic risk score based on a genetic enrichment approach
Wurst C, Maixner F, Valverde G, Tessmann B, Krause-Kyora B, Krause J, Del Vesco P, Helmbold-Doyé J, Hotz G, Thompson R, Zink A (2022)
Presentazione

Conference: 10th World Congress on Mummy Studies | Bolzano | 5.9.2022 - 9.9.2022

Four thousand years of maternal ancestry in ancient Egypt illuminated by mitochondrial genome sequencing
Mussauer A, Wurst C, Paladin A, Coia V, Maixner F, Helmbold-Doyé J, Del Vesco P, Rosendahl W, Zink A (2022)
Presentazione

Conference: 10th World Congress on Mummy Studies | Bolzano | 5.9.2022 - 9.9.2022

The Lady from Basel’s Barfüsserkirche – Molecular confirmation of the Mummy’s identity through mitochondrial DNA of living relatives spanning 22 generations
Wurst C, Maixner F, Castella V, Cipollini G, Hotz G, Zink A (2022)
Articolo su rivista
Forensic Science International: Genetics

https://doi.org/10.1016/j.fsigen.2021.102604

https://hdl.handle.net/10863/19187

Ancient DNA analysis of rare genetic bone disorders
Maixner F, Gresky J, Zink A (2021)
Articolo su rivista
International Journal of Paleopathology

Ulteriori informazioni: https://doi.org/10.1016/j.ijpp.2021.04.009

https://doi.org/10.1016/j.ijpp.2021.04.009

https://hdl.handle.net/10863/17193

Correlation of atherosclerosis and osteoarthritis in ancient Egypt: A standardized evaluation of 45 whole-body CT examinations
Panzer S, Augat P, Sprenger M, Zesch S, Rosendahl W, Sutherland ML, Thompson RC, Paladin A, Zink A (2021)
Articolo su rivista
International Journal of Paleopathology

Ulteriori informazioni: https://doi.org/10.1016/j.ijpp.2021.04.004

https://doi.org/10.1016/j.ijpp.2021.04.004

https://hdl.handle.net/10863/17151

Molekulargenetische Überprüfung der historischen Identität von Anna Catharina Bischoff
Wurst C, Castella V, Cipollini G, Maixner F, Zink A (2021)
Contributo in un libro
Anna Catharina Bischoff. Die Mumie aus der Barfüsserkirche: Rekonstruktion einer Basler Frauenbiografie des 18. Jahrhunderts

https://hdl.handle.net/10863/19764

Molekulargenetische Hinweise zum physischen Erscheinungsbild
Wurst C, Maixner F, Zink A (2021)
Contributo in un libro
Anna Catharina Bischoff. Die Mumie aus der Barfüsserkirche: Rekonstruktion einer Basler Frauenbiografie des 18. Jahrhunderts

https://hdl.handle.net/10863/19765

Minimally-Invasive Bone Biopsies of Fully Wrapped Mummies Guided by Computed Tomography and Fibre-Optic Endoscopy: Suggested Methods and Guidelines
Wurst C, Paladin A, Wann LS, Frohlich B, Fritsch KO, Rowan CJ, Sutherland ML, Sutherland JD, Michalik D, Allam AH, Zesch S, Rosendahl W, Seyfried F, Thompson RC, Thomas GS, Zink A (2020)
Articolo su rivista
Journal of Archaeological Science: Reports

https://doi.org/10.1016/j.jasrep.2020.102363

https://hdl.handle.net/10863/14773

Atherogenesis in Human Mummified Remains: Archaeogenetics
Wurst C, Maixner F, Zink A, The HORUS Study Team (2019)
Presentazione

Conference: EMBO Practical Course - Bioinformatics and genome analyses | San Michele all'Adige | 16.6.2019 - 30.6.2019

https://hdl.handle.net/10863/13020

Possible evidence for care and treatment in the Tyrolean Iceman
Zink A, Samadelli M, Gostner P, Piombino-Mascali D (2019)
Articolo su rivista
International Journal of Paleopathology

https://doi.org/10.1016/j.ijpp.2018.07.006

https://hdl.handle.net/10863/6828

Preliminary Biopsy findings, Turin mummies
Frohlich B, Wurst C, Paladin A, Zink A (2017)
Presentazione

Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017

Preliminary aDNA analysis of Egyptian mummies of the Ägyptisches Museum in Berlin
Wurst C (2017)
Presentazione

Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017

A target enrichment capture for atherosclerotic cardiovascular disease SNPs in human mummies
Wurst C, Maixner F, Coia V, Zink A (2017)
Presentazione

Search for Cardiovascular Genetic Risk Factors in ancient DNA of Egyptian Mummified Human Remains
Wurst C, Wann S, Thompson R, Maixner F, Allam A, Finch C, Frohlich B, Sutherland L, Sutherland J, Narula N, Narula J, Fritsch K, Rowan C, Michalik D, Paladin A, Zesch S, Rosendahl W, Huppertz A, Seyfried F, Thomas G, Zink A (2016)
Presentazione

Conference: 9th World Congress on Mummy Studies | Lima | 10.8.2016 - 13.8.2016

Atherosclerosis in ancient mummified human remains: Linking genetic predisposition with the occurrence of calcified plaques
Wurst C, Wann S, Thompson R, Keller A, Maixner F, Allam A, Finch C, Frohlich B, Kaplan H, Lombardi G, Sutherland L, Sutherland J, Watson L, Cox S, Miyamoto M, Narula J, Stewart A, Thomas G, Zink A (2015)
Presentazione

Conference: 83rd EAS Congress | Glasgow | 22.3.2015 - 25.3.2015

Two studies show atherosclerosis has been with humans for much longer than assumed

CT scans and genetic analyses of ancient human remains indicate that atherosclerosis has been present in humans for thousands of years.

02 February 2024

Genetic Predisposition of Atherosclerotic Cardiovascular Disease in Ancient Human Remains

Our researchers have published a new paper in the journal Annals of Global Health to enlighten the genetic burden of our ancestors for the not just modern disease atherosclerosis, with our PhD student ...

Our partners

1 - 6

Mount Sinai Hospital
Smithsonian , National Museum of Natural History
University of Vienna, Department of Computational Systems Biology
Long Beach Memorial Medical Center, Long Beach, and University of California, Irvine, Irvine, CA, ...
Saint Luke's Mid America Heart Institute, and University of Missouri–Kansas City School of Medicine, ...
Columbia St. Mary's Hospital

Project Team

1 - 2

Christina Wurst

Project Manager

Albert Zink

Vice Manager

Projects

1 - 10

Project

BOLD

L'analisi paleogenetica di sessanta mummie boliviane fornisce preziose informazioni sulla storia ...

Duration: January 2024 - December 2024Funding: Provincial P.-L.P. 14. Mobility ...

Project

CeltUDAlps

"Celti" nelle Alpi: modelli di origine e mobilità su entrambi i lati delle Alpi nella tarda età del ...

Duration: January 2021 - December 2023Funding: Provincial P.-L.P. 14. Research ...

Project

MUMBO

Studio bioarcheologico di resti umani mummificati precolombiani dalla Bolivia. Comprensione e tutela ...

Duration: November 2021 - November 2023Funding: Provincial P.-L.P. 14. Seal of ...

Project

PrehistoricAlps

Diversità genomica degli individui preistorici dal territorio dell'Iceman nelle Alpi italiane ...

Duration: October 2020 - December 2022Funding: Provincial P.-L.P. 14. Research ...

Project