New study reveals key biomarkers associated with overall health

This study, conducted as part of our CHRIS study (link to CHRIS page) (Cooperative Health Research in South Tyrol), has identified important biomarkers associated with general health and organ-specific morbidity.

The researchers analyzed metabolomic and proteomic data from 3,142 adults in the CHRIS study cohort. By analyzing cross-sectional metabolomic and proteomic data from fasting serum and plasma samples, we quantified 174 metabolites and 148 proteins. Health status was assessed using the Cumulative Illness Rating Scale (CIRS) Comorbidity Index (CMI), which assesses morbidity in 14 organ systems. Overall, we identified 21 metabolites and 10 proteins as relevant predictors of health status, independent of age. In particular, serotonin and glutamate emerged as relevant predictors of health status. In addition, several metabolites and proteins were associated with endocrine, cardiovascular and renal morbidity, with circulating serotonin identified as a potential novel predictor of total morbidity.

These findings highlight the potential of multi-omics data to provide deeper insights into the molecular basis of age-related diseases and general health. By identifying these biomarkers, we can pave the way for early detection and prevention strategies for age-related morbidity.

Read the full article here: https://www.nature.com/articles/s41598-024-75627-3